Effects of Vaccination against GDF9 and BMP15 on Fertility and Ovarian Function in the White-tailed Deer

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Effects of Vaccination against GDF9 and BMP15 on Fertility and Ovarian Function in the White-tailed Deer

The physiological mechanisms controlling ovarian follicular growth and ovulation involve a complex exchange of systemic signals and a localized exchange of molecules between the oocyte and surrounding somatic cells. It has been demonstrated that the oocyte itself plays an essential role in regulating these processes by secreting two key regulatory proteins: bone morphogenetic protein-15 (BMP15)...

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BMP15 and GDF9 Gene Mutations in Premature Ovarian Failure

BACKGROUND Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles before the age of 40, representing one major cause of female infertility. Mutations in bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) have been shown to be associated with POF. METHODS Genomic DNA was isolated from 52 idiopathic premat...

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ژورنال

عنوان ژورنال: Proceedings of the Vertebrate Pest Conference

سال: 2014

ISSN: 2641-273X

DOI: 10.5070/v426110697